Peter D. Keightley - Publications


2021

He, F., Steige, K. A., Kovacova, V., Goebel, U., Bouzid, M, Keightley, P. D., Beyer, A. and de Meaux, J. (2021).
Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity.
Nature Communications 12: 3376. [Article]

Craig, R. J., Hasan, A. R., Ness, R. W. and Keightley, P. D. (2021).
Comparative genomics of Chlamydomonas.
Plant Cell 33: 1016-1041. [Article]

2020

Chebib, J., Jackson, B. C., López-Cortegano, E. L., Tautz, D. and Keightley, P. D. (2020).
Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site.
Heredity 126: 107-116. [Article]

2019

Craig, R. J., Boendel, K. B., Arakawa, K., Nakada, T., Ito, T., Bell, G., Colegrave, N., Keightley, P. D. and Ness, R. W. (2019).
Patterns of population structure and complex haplotype sharing among field isolates of the green alga Chlamydomonas reinhardtii.
Molecular Ecology 28: 3977-3993. [Article]

Boendel, K. B., Kraemer, S. A., Samuels, T. S., McClean, D., Lachapelle, J., Ness, R. W., Colegrave, N. and Keightley, P. D. (2019).
Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii.
PLoS Biology 17: e3000192. [Article]

2018

Booker, T. R, and Keightley, P. D. (2018).
Understanding the factors that shape patterns of nucleotide diversity in the house mouse genome.
Molecular Biology and Evolution 35: 2971-2988. [PDF]

Keightley, P. D. and Jackson, B. C. (2018).
Inferring the probability of the derived vs. the ancestral allelic state at a polymorphic site.
Genetics 209: 897-906. [PDF]

Katju, V., Packard, L. B. and Keightley, P. D. (2018).
Fitness decline under osmotic stress in Caenorhabditis elegans populations subjected to spontaneous mutation accumulation at varying population sizes.
Evolution 72: 1000-1008. [PDF]

2017

Kraemer, S. A., Boendel, K.B., Ness, R. W., Keightley, P. D. and Colegrave, N. (2017).
Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii.
Evolution 71: 2918-2929. [PDF]

Booker, T. R., Jackson B. C. and Keightley, P. D. (2017).
Detecting positive selection in the genome.
BMC Biology 15: 98. [PDF]

Booker, T. R., Ness, R. W. and Keightley, P. D. (2017).
The recombination landscape in wild house mice inferred using population genomic data.
Genetics 207: 297-309. [PDF]

Konrad, A., Thompson, O., Waterston, R. H., Moerman, D. G., Keightley, P. D., Bergthorsson, U. and Katju, V. (2017).
Mitochondrial mutation rate, spectrum and heteroplasmy in Caenorhabditis elegans spontaneous mutation accumulation lines of differing population size.
Molecular Biology and Evolution 34: 1319-1334. [PDF]

2016

Puckett, E. R., Park, J., Combs, J., Blum, M. J., Bryant, J. E., Caccone, A., Costa, F., Deinum, E. E., Esther, A., Himsworth, C. G., Keightley, P. D., Ko, A., Lundkvist, A., McElhinney, L. M., Morand, S., Robins, J., Russell, J., Strand, T. M., Suarez, O., Yon, L. and Munshi-South, J. (2016).
Global population divergence and admixture of the brown rat (Rattus norvegicus).
Proceedings of the Royal Society of London Series B 283: 20161762. [PDF]

Keightley, P. D., Campos, J. L., Booker T. R. and Charlesworth, B. (2016).
Inferring the frequency spectrum of derived variants to quantify adaptive molecular evolution in protein-coding genes of Drosophila melanogaster.
Genetics 203: 975-984. [PDF]

Kraemer, S. A., Morgan, A. D., Ness, R. W., Keightley, P. D. and Colegrave, N. (2016).
Fitness effects of new mutations in Chlamydomonas reinhardtii across two stress gradients.
Journal of Evolutionary Biology 29: 583-593. [PDF]

Ness, R. W., Kraemer, S. A., Colegrave, N. and Keightley, P. D. (2016).
Direct estimate of the spontaneous mutation rate uncovers effects of drift and recombination on the Chlamydomonas reinhardtii plastid genome.
Molecular Biology and Evolution 33: 800-808. [PDF]

2015

Caballero, A, Tenesa, A. and Keightley, P. D. (2015).
The nature of genetic variation for complex traits revealed by GWAS and Regional Heritability Mapping analyses.
Genetics 201: 1601-1613. [PDF]

Wiberg, R. A. W., Halligan, D. L., Ness, R. W., Necsulea, A., Kaessmann, H. and Keightley, P. D. (2015).
Assessing recent selection and functionality at long non-coding RNA loci in the mouse genome.
Genome Biology and Evolution 7: 2432-2444. [PDF]

Ness, R. W., Morgan, A. D., Radhakrishnan, V., Colegrave, N. and Keightley, P. D. (2015).
Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii.
Genome Research 25: 1739-1749. [PDF]

Deinum, E. E., Halligan, D. L., Ness, R. W., Zhang, Y.-H., Cong, L., Zhang, J.-X. and Keightley, P. D. (2015).
Recent evolution in Rattus norvegicus is shaped by declining effective population size.
Molecular Biology and Evolution 32: 2547-2558. [PDF]

Keightley, P. D., Pinharanda, A., Ness, R. W., Simpson, F., Dasmahapatra, K. K., Mallet, J., Davey, J. W. and Jiggins, C. D. (2015).
Estimation of the spontaneous mutation rate in Heliconius melpomene.
Molecular Biology and Evolution 32: 239-243. [PDF]

Katju, V., Packard, L. B., Bu, L., Keightley, P. D. and Bergthorsson, U. (2015).
Fitness decline in spontaneous mutation accumulation lines of Caenorhabditis elegans with varying effective population sizes.
Evolution 69: 104-116. [PDF]

2014

Morgan, A. D., Ness, R. W., Keightley, P. D., and Coelgrave N. (2014).
Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii.
Evolution 68: 2589-2602. [PDF]

Kousathanas, A., Halligan, D. L. and Keightley, P. D. (2014).
Faster-X adaptive protein evolution in house mice.
Genetics 196: 1131-1143. [PDF]

Keightley, P. D., Ness, R. W., Halligan, D. L. and Haddrill, P. R. (2014).
Estimation of the spontaneous mutation rate per nucleotide site in a Drosophila melanogaster full-sib family.
Genetics 196: 313-320. [PDF]

2013

Halligan, D. L., Kousathanas, A., Ness, R. W., Harr, B., Eory, L., Keane, T. M., Adams, D. J. and Keightley, P. D. (2013).
Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodents.
PLoS Genetics 193: 1197-1208. [Article]

Kousathanas, A. and Keightley, P. D. (2013).
A comparison of models to infer the distribution of fitness effects of new mutations.
Genetics 193: 1197-1208. [PDF]

2012

Ness, R. W., Zhang, Y.-H., Cong, L., Wang, Y., Zhang, J.-X. and Keightley, P. D. (2012).
Nuclear gene variation in wild brown rats.
Genes|Genomes|Genetics 2: 1661-1664. [PDF]

Hartfield, M., Otto, S. P. and Keightley, P. D. (2012).
The maintenance of obligate sex in finite, structured populations subject to recurrent beneficial and deleterious mutation.
Evolution 66: 3658-3669. [PDF]

Ness, R. W., Morgan, A. D., Colegrave, N. and Keightley, P. D. (2012).
Estimate of the spontaneous mutation rate in Chlamydomonas reinhardtii.
Genetics 192: 1447-1454. [PDF]

Lesecque, Y., Keightley, P. D. and Eyre-Walker, A. (2012).
A resolution of the mutation load paradox in humans.
Genetics 191: 1321-1330. [PDF]

Hartfield, M. and Keightley, P. D. (2012).
Current hypotheses for the evolution of sex and recombination.
Integrative Zoology 7: 192-209. [PDF]

Gossmann, T. I., Keightley, P. D. and Eyre-Walker, A. (2012).
The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.
Genome Biology and Evolution 4: 658-667. [PDF]

Keightley, P. D. and Eyre-Walker, A. (2012).
Estimating the rate of adaptive molecular evolution when the evolutionary divergence between species is small.
Journal of Molecular Evolution 74: 61-68. [PDF]

Keightley, P. D. (2012).
Rates and fitness consequences of new mutations in humans.
Genetics 190: 295-304. [PDF]

2011

Schneider, A., Charlesworth, B., Eyre-Walker, A. and Keightley, P. D. (2011).
A method for inferring the rate of occurrence and fitness effects of advantageous mutations.
Genetics 189: 1427-1437. [PDF]

Halligan, D. L., Oliver, F., Guthrie, J., Stemshorn, K. C., Harr, B. and Keightley, P. D. (2011).
Positive and negative selection in murine ultra-conserved noncoding elements.
Molecular Biology and Evolution 28: 2651-2660. [PDF]

Keightley, P. D., and Halligan, D. L. (2011).
Inference of site frequency spectra from high-throughput sequence data: quantification of selection on nonsynonymous and synonymous sites in humans.
Genetics 188: 931-940. [PDF]

Keightley, P. D., Eöry, L., Halligan, D. L. and Kirkpatrick, M. (2011).
Inference of mutation parameters and selective constraint in mammalian coding sequences by approximate Bayesian computation.
Genetics 187: 1153-1161. [PDF]

Kousathanas, A., Oliver, F., Halligan, D. L. and Keightley, P. D. (2011).
Positive and negative selection on noncoding DNA close to protein-coding genes in wild house mice.
Molecular Biology and Evolution 28: 1183-1191. [PDF]

2010

Hartfield, M., Otto, S. P. and Keightley, P. D. (2010).
The role of advantageous mutations in enhancing the evolution of a recombination modifier.
Genetics 184: 1153-1164. [PDF]

Keightley, P. D. and Eyre-Walker, A. (2010).
What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?
Phil. Trans. R. Soc. B 365: 1187-1193. [PDF]

Halligan, D. L., Oliver, F., Eyre-Walker, A., Harr, B. and Keightley, P. D. (2010).
Evidence for pervasive adaptive protein evolution in wild mice.
PLoS Genetics 6: e1000825. [Article]

Eöry, L., Halligan, D. L. and Keightley, P. D. (2010).
Distribution of selectively constrained sites and the deleterious mutation rate in the hominid and murid genomes.
Molecular Biology and Evolution 27: 177-192. [PDF]

2009

Marion de Procé, S., Halligan, D. L., Keightley, P. D. and Charlesworth, B. (2009).
Patterns of DNA-sequence divergence between
Drosophila miranda and D. pseudoobscura.
Journal of Molecular Evolution 69: 601-611. [PDF]

Halligan, D. L. and Keightley, P. D. (2009).
Spontaneous mutation accumulation studies in evolutionary genetics.
Annual Review of Ecology, Evolution and Systematics 40: 151-172. [PDF]

Eyre-Walker, A. and Keightley, P. D. (2009).
Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.
Molecular Biology and Evolution 26: 2097-2108. [PDF]

Keightley, P. D., Trivedi, U., Thomson, M., Oliver, F., Kumar S. and Blaxter, M. L. (2009).
Analysis of the genome sequences of three
Drosophila melanogaster spontaneous mutation accumulation lines.
Genome Research 19: 1195-1201. [PDF]

Keightley, P. D. and Halligan, D. L. (2009).
Analysis and implications of mutational variation.
Genetica 136: 359-369. [PDF]

2008

Gaffney, D. J. and Keightley, P. D. (2008).
Effect of the assignment of ancestral CpG state on the estimation of nucleotide substitution rates in mammals.
BMC Evolutionary Biology 8: 265. [Article]

Haag-Liautard, C., Coffey, N., Houle, D., Lynch, M., Charlesworth, B. and Keightley, P. D. (2008).
Direct estimation of the mitochondrial DNA mutation rate in
D. melanogaster.
PLoS Biology 6: e204. [Article]

2007

Guo, X., Wang, Y., Keightley, P. D. and Fan, L. (2007).
Patterns of selective constraints in noncoding DNA of rice.
BMC Evolutionary Biology 7: 208. [Article]

Wang, J., Keightley, P. D. and Halligan, D. L. (2007).
Effect of divergence time and recombination rate on molecular evolution of
Drosophila INE-1 transposable elements and other candidates for neutrally evolving sites.
Journal of Molecular Evolution 65: 627-639. [PDF]

Keightley, P. D. and Eyre-Walker, A. (2007).
Joint inference of the distribution of fitness effects of deleterious mutations and population demography based on nucleotide polymorphism frequencies.
Genetics 177: 2251-2261. [PDF]

Drosophila 12 Genomes Consortium (2007).
Evolution of genes and genomes on the
Drosophila phylogeny.
Nature 450: 203-218. [Pubmed]

Eyre-Walker, A. and Keightley, P. D. (2007).
The distribution of fitness effects of new mutations.
Nature Reviews Genetics 8: 610-618. [PDF]

Haag-Liautard, C., Dorris, M., Maside, X., Macaskill, S., Halligan, D. L., Houle, D., Charlesworth, B. and Keightley, P. D. (2007).
Direct estimation of per nucleotide and genomic deleterious mutation rates in
Drosophila.
Nature 445: 82-85. [PDF]

2006

Gaffney, D. J. and Keightley, P. D. (2006).
Genomic selective constraints in murid noncoding DNA.
PLoS Genetics 2: e204. [Article]

Keightley, P. D. and Otto, S. P. (2006).
Interference among deleterious mutations favours sex and recombination in finite populations.
Nature 443: 89-92. [PDF]

Wang, J., Keightley, P. D. and Johnson, T. (2006).
MCALIGN2: faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution.
BMC Bioinformatics 7: 292. [Article]

Christians, J. K., Hoeflich, A. and Keightley, P. D. (2006).
PAPPA2, an enzyme that cleaves an insulin-like growth factor binding protein, is a candidate gene for a QTL affecting body size in mice.
Genetics 173: 1547-1553. [PDF]

Halligan, D. L. and Keightley, P. D. (2006).
Ubiquitous selective constraints in the
Drosophila genome revealed by a genome-wide interspecies comparison.
Genome Res. 16: 875-884. [PDF]

Keightley, P. D., Lercher, M. J. and Eyre-Walker, A. (2006).
Understanding the degradation of hominid gene control.
PLoS Comput. Biol. 2: e19. [Article]

2005

Keightley, P. D., Kryukov, G. V., Sunyaev, S., Halligan, D. L. and Gaffney, D. J. (2005).
Evolutionary constraints in conserved nongenic sequences of mammals.
Genome Res. 15: 1373-1378. [PDF]

Gaffney, D. J. and Keightley, P. D. (2005).
The scale of mutational variability in the murid genome.
Genome Res. 15: 1086-1094. [PDF]

Marais G., Nouvellet P., Keightley P. D. and Charlesworth, B. (2005).
Intron size and exon evolution in Drosophila.
Genetics 170: 481-485. [PDF]

Oliver, F., Christians, J. K., Liu, X., Rhind, S., Verma, V., Davison, C., Brown, S. D. M., Denny, P. and Keightley, P. D. (2005).
Regulatory variation at glypican-3 underlies a major growth QTL in mice.
PLoS Biology 3: 872-877. [Article]

Keightley, P. D., Lercher, M. J. and Eyre-Walker, A. (2005).
Evidence for widespread degradation of gene control regions in hominid genomes.
PLoS Biology 3: 282-288. [Article]

Stylianou, I. M., Clinton, M. I., Keightley, P. D., Pritchard, C., Lallane, Z., Bünger, L. and Horvat, S. (2005).
Microarray gene expression analysis of the Fob3b obesity QTL identifies positional candidate gene Sqle and perturbed cholesterol and glycolysis pathways.
Physiological Genomics 20: 224-232. [PDF]

Keightley, P. D. and Charlesworth, B. (2005).
Genetic instability of
C. elegans comes naturally.
Trends in Genetics 21: 67-70. [PDF]

Christians, J. K. and Keightley, P. D. (2005).
Finding genes that cause complex trait variation.
Current Biology 15: R19-R21. [PDF]

2004

Wesche, P. L., Gaffney, D. J. and Keightley, P. D. (2004).
DNA sequence error rates in Genbank records estimated using the mouse genome as a reference.
DNA Sequence 15: 362-364. [PDF]

Gantenbein, B. and Keightley, P. D. (2004).
Rates of molecular evolution in nuclear genes of East Mediterranean scorpions.
Evolution 58: 2486-2497. [PDF]

Christians, J. K. and Keightley, P. D. (2004).
Fine mapping of a murine growth locus to a 1.4cM region and resolution of linked QTL.
Mamm. Genome 15: 482-491. [PDF]

Gaffney, D. J. and Keightley, P. D. (2004).
Unexpected conserved non-coding DNA blocks in mammals.
Trends. Genet. 20: 332-337. [PDF]

Stylianou, I. M., Christians, J. K., Keightley, P. D., Bünger, L., Clinton, M., Bulfield, G. and Horvat, S. (2004).
Genetic complexity of an obesity QTL (Fob3) revealed by detailed genetic mapping.
Mamm. Genome 15: 472-481. [PDF]

Keightley, P. D. (2004).
Comparing analysis methods for mutation-accumulation data.
Genetics 167: 551-553. [PDF]

Keightley, P. D. and Johnson, T. (2004).
MCALIGN: stochastic alignment of noncoding DNA sequences based on an evolutionary model of sequence evolution.
Genome Res. 14: 442-450. [PDF]

Keightley, P. D. (2004).
Mutational variation and long-term selection response.
Plant Breeding Reviews 24: part 1 227-247. [PDF]

Halligan, D. L., Eyre-Walker, A. Andolfatto, P. and Keightley, P. D. (2004).
Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila.
Genome Res. 14: 273-279. [PDF] [Publication support]

2003

Halligan, D. L., Peters, A. D., & Keightley, P. D. (2003).
Estimating numbers of EMS-induced mutations affecting life history traits in
Caenorhabditis elegans in crosses between inbred sublines.
Genet. Res. 82: 191-205. [PDF]

Keightley, P. D. and Gaffney, D. J. (2003).
Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents.
Proc. Natl. Acad. Sci. USA 100: 13402-13406. [PDF]

Peters, A. D., Halligan, D. L., Whitlock, M. C. and Keightley, P. D. (2003).
Dominance and overdominance of mildly deleterious induced mutations for fitness traits in
Caenorhabditis elegans.
Genetics 165: 589-599. [PDF]

Keightley, P. D. and Lynch, M. (2003).
Towards a realistic model of mutations affecting fitness.
Evolution 57: 683-685. [PDF]

Christians, J. K., Bingham, V., Oliver, F., Heath, T. and Keightley, P. D. (2003).
Characterisation
of a QTL affecting skeletal size in mice.
Mammalian Genome
, 14: 175-183. [PDF]

Halligan , D. L. and Keightley, P. D. (2003).
How many lethal alleles?
Trends in Genetics 19: 57-59. [PDF]

2002

Eyre-Walker, A., Keightley,  P. D.,  Smith, N. G. C. and Gaffney, D. (2002).
Quantifying the slightly deleterious model of molecular evolution.

Molecular Biology and Evolution
19: 2142-2149. [PDF]

Barton, N. H. and Keightley, P. D. (2002).
Understanding quantitative genetic variation.

Nature Reviews Genetics
3: 11-21. [PDF]

Millar, C. B., Guy, J., Sansom, O. J., Selfridge, J., MacDougall, E., Hendrich, B., Keightley, P. D., Bishop, S. M., Clarke, A. R. and Bird. A. (2002).
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.
Science
297: 403-405.

Azevedo, R. B. R., Keightley, P. D. Laurén-Määttä, C., Vassilieva, L. L., Lynch, M. and Leroi, A. M. (2002).
Spontaneous mutational variation for body size in
Caenorhabditis elegans.
Genetics,
162: 755-765. [PDF] .

Christians, J. K. and Keightley, P. D. (2002).
Dissecting the genetic basis of phenotypic variation.
Current Biology
12: R415-R416.

2001

Keightley, P. D. and Eyre-Walker, A. (2001).
Sex and U - Response to Kondrashov.
Trends in Genetics
17: 77-78.

Liu, X., Oliver, F., Brown, S. D. M., Denny, P., and Keightley, P. D. (2001).
High resolution quantitative trait locus mapping for body weight in mice by recombinant progeny testing.

Genetical Research
77: 191-197. [PDF]

Liu, X., Bünger, L. and Keightley, P. D. (2001).
Characterisation of a major X-linked QTL influencing body weight in mice.
Journal of Heredity 92: 355-357. [PDF]

2000

Horvat, S., Bünger, L., Falconer, V. M., Mackay, P., Law, A., Bulfield, G. and Keightley, P. D. (2000).
Mapping of obesity QTLs in a cross between mouse lines divergently selected on fat content.

Mammalian Genome
11: 2-7. [PDF]

Keightley, P. D. and Bataillon, T. A. (2000).
Multi-generation maximum likelihood analysis applied to mutation accumulation experiments in
Caenorhabditis elegans.
Genetics
154: 1193-1201. [PDF]

Keightley, P. D., Davies, E. K., Peters, A. D. and Shaw. R. G. (2000).
Properties of EMS-induced mutations affecting life history traits in
Caenorhabditis elegans and inferences about bivariate distributions of mutation effects.
Genetics
156: 143-154. [PDF]

Keightley, P. D. and Eyre-Walker, A. (2000).
Deleterious mutations and the evolution of sex.
Science 290 : 331-333.[PDF]

Peters, A. D. and Keightley, P. D. (2000).
A test for epistasis among induced mutations in
Caenorhabditis elegans.
Genetics
156: 1635-1647. [PDF]

Johnson, T. and Keightley, P. D. (2000).
Quantitative genetics: Resolving wing shape genes.
Current Biology
10: R113-R115.

1995-1999

Fry, J. D., Keightley, P. D., Heinsohn, S. L. and Nuzhdin, S. V. (1999).
New estimates of rates and effects of mildly deleterious mutation in Drosophila melanogaster.
Proc. Natl. Acad. Sci. USA
96: 574-579.

Keightley, P. D. (1999).
Analysis of mutation accumulation experiments - response to Deng, Li & Li.
Genetical Research
74: 87-91. [PDF]

Eyre-Walker, A. and Keightley, P. D. (1999).
High genomic deleterious mutation rates in hominids.

Nature
397: 344-347. [PDF]

Morris, K. H., Ishikawa, A. and Keightley, P. D. (1999).
Quantitative trait loci for growth traits in C57BL/6J x DBA/2J mice.

Mammalian Genome
10: 225-228. [PDF]

Davies, E. K., Peters, A. D. and Keightley, P. D. (1999).
High frequency of cryptic deleterious mutations in
Caenorhabditis elegans.
Science
285: 1745-1747. [PDF]

Keightley, P. D. and Knott, S. A. (1999).
Testing the correspondence between map positions of quantitative trait loci.
Genetical Research
74: 323-328.

Keightley, P. D. and Eyre-Walker, A. (1999).
Terumi Mukai and the riddle of deleterious mutation rates.
Genetics 153: 515-523. [PDF]

Keightley, P. D. (1998).
Genetic basis of response to 50 generations of selection on body weight in inbred mice.
Genetics 148: 1931-1939. [PDF]

Caballero, A. and Keightley, P. D. (1998).
Inferences on genome-wide deleterious mutation rates in inbred populations of Drosophila and mice.
Genetica
102/103: 229-239.

Wang, J., Caballero, A., Keightley, P. D. and Hill, W. G. (1998).
Bottleneck effect on genetic variance: a theoretical investigation of the role of dominance.
Genetics
150 : 435-447. [PDF]

Keightley, P. D. (1998).
Inference of genome wide mutation rates and distributions of mutation effects for fitness traits: a simulation study.

Genetics
150: 1283-1293. [PDF]

Keightley, P. D., Morris, K. H., Ishikawa, A., Falconer, V. M. and Oliver, F. (1998).
Test of candidate gene-quantitative trait locus association applied to fatness in mice.

Heredity
81 : 630-637. [Article]

Nuzhdin, S. V., Keightley, P. D., Pasyukova, E. G. and Morozova, E. A. (1998).
Mapping quantitative trait loci affecting Drosophila melanogaster sternopleural bristle number using changes of marker allele frequencies in divergently selected lines.
Genetical Research
72: 79-91. [PDF]

Keightley, P. D. and Ohnishi, O. (1998).
EMS-induced polygenic mutation rates for nine quantitative characters in
Drosophila melanogaster.
Genetics 148: 753-766. [PDF]

Keightley, P. D., Caballero, A. and Garcia-Dorado, A. (1998).
Surviving under mutation pressure.
Current Biology
8: R235-237.

Keightley, P. D. and Caballero, A. (1997).
Genomic mutation rates for lifetime reproductive output and lifespan in
Caenorhabditis elegans.
Proc. Natl. Acad. Sci. USA
94: 3823-3827. [PDF]

Rance, K. A., Hill, W. G. and Keightley, P. D. (1997).
Mapping quantitative trait loci for body weight on the X chromosome in mice. I. Analysis of a reciprocal F2 population.
Genetical Research 70: 117-124. [PDF]

Rance, K. A., Hill, W. G. and Keightley, P. D. (1997).
Mapping quantitative trait loci for body weight on the X chromosome in mice. II. Analysis of congenic backcrosses.
Genetical Research 70: 125-133. [PDF]

Caballero, A., Keightley, P. D. and Turelli, M. (1997).
Average dominance for polygenes: drawbacks of regression estimates.
Genetics 147: 1487-1490. [PDF]

Keightley, P. D. (1996).
A metabolic basis for dominance and recessivity.
Genetics 143: 621-625. [PDF]

Keightley, P. D. (1996).
Metabolic models of selection response.
Journal of Theoretical Biology 182: 311-316. [PDF]

Keightley, P. D. (1996).
Nature of deleterious mutation load in Drosophila.
Genetics 144: 1993-1999. [PDF]

Keightley, P. D., Hardge, T., May, L. and Bulfield, G. (1996).
A genetic map of quantitative trait loci for body weight in the mouse.
Genetics 142: 227-235. [PDF]

Ishikawa, A. and Keightley, P. D. (1996).
Genetic mapping of the rimy mutation on mouse chromosome 11.
Mouse Genome 94: 871-873.

Caballero, A., Keightley, P. D. and Hill, W. G. (1995).
Accumulation of mutations affecting body weight in inbred mouse lines.
Genetical Research 65: 145-149. [PDF]

Keightley, P. D. (1995).
Loci with large effects.
Current Biology 5: 485-487.

Kay, S. J. E. and Keightley, P. D. (1995).
Low rates of proviral integration in SWR/J-RF/J hybrid mice.
Genetical Research 66: 45-52. [PDF]

Heath, S. C., Bulfield, G., Thompson, R. and and Keightley, P. D. (1995).
Rates of change of genetic parameters of body weight in selected mouse lines.
Genetical Research 66: 19-25. [PDF]

1990-1994

Keightley, P. D. (1994).
The distribution of mutation effects on viability in Drosophila melanogaster.
Genetics 138: 1315-1322. [PDF]

Keightley, P. D. (1994).
Recovery of phylogenetic information with microsatellite markers.
Mouse Genome 92: 683-685.

Caballero, A. and Keightley, P. D. (1994).
A pleiotropic nonadditive model of variation in quantitative traits.
Genetics 138: 883-900. [PDF]

Keightley, P. D. and Bulfield, G. (1993).
Detection of quantitative trait loci from frequency changes at marker loci under selection.
Genetical Research 62: 195-203. [PDF]

Nuzhdin, S. V., Keightley, P. D. and Pasyukova, E. (1993).
The use of retrotransposons as markers for mapping genes responsible for fitness differences between related Drosophila melanogaster strains.
Genetical Research 62: 125-131. [PDF]

Keightley, P. D. Evans, M. J. and Hill, W. G. (1993).
Effects of multiple retrovirus insertions on quantitative traits of mice.
Genetics 135: 1099-1106. [PDF]

Keightley, P. D., Mackay, T. F. C. and Caballero, A. (1993).
Accounting for bias in estimates of the rate of polygenic mutation.
Proceedings: Biological Sciences 253: 291-296. [PDF]

Keightley, P. D. and Hill, W. G. (1992).
Quantitative genetic variation in body size of mice from new mutations.
Genetics 131: 693-700. [PDF]

Caballero, A., Keightley, P. D. and Hill, W. G. (1991).
Strategies for increasing fixation probabilities of recessive mutations.
Genetical Research 58: 129-38. [PDF]

Keightley, P. D. (1991).
Genetic variance and fixation probabilities at quantitative trait loci in mutation-selection balance.
Genetical Research 58: 139-144. [PDF]

Keightley, P. D. and Hawkins, S. (1991).
Rimy: a new mutation affecting coat colour and body size.
Mouse Genome 89: 410.

Keightley, P. D. and Hill, W. G. (1990).
Variation maintained in quantitative traits with mutation selection balance: pleiotropic side-effects on fitness traits.
Proceedings of the Royal Society B 242: 95-100. [PDF]

Upper paleolothic

Keightley, P. D. and Hill, W. G. (1989).
Quantitative variability maintained by mutation-stabilizing selection balance: sampling variation and response to subsequent directional selection.
Genetical Research 54: 45-57. [PDF]

Keightley, P. D. (1989).
Models of quantitative variation of flux in metabolic pathways.
Genetics 121: 869-876. [PDF]

Keightley, P. D. and Hill, W. G. (1988).
Quantitative genetic variability maintained by mutation-stabilizing selection balance in finite populations.
Genetical Research 52: 33-42. [PDF]

Keightley, P. D. and Hill, W. G. (1988).
Interrelations of mutation, population size, artificial and natural selection.
In Proceedings of the Second International Conference on Quantitative Genetics (ed. B. S. Weir, E. J. Eisen, M. M. Goodman and G. Namkoong), pp 57-70. Sunderland, Massachusetts: Sinauer.

Keightley, P. D. and Hill, W. G. (1987).
Directional selection and variation in finite populations.
Genetics 117: 573-582. [PDF]

Keightley, P. D. and Kacser, H. (1987).
Dominance, pleiotropy and metabolic structure.
Genetics 117: 319-329. [PDF]

Keightley, P. D. and Hill, W. G. (1983).
Effects of linkage on response to directional selection from new mutations.
Genetical Research 42 :193-206. [PDF]